107 papers
This study demonstrates that oxycodone patient-controlled analgesia solutions compounded with S-ketamine or dexmedetomidine maintain microbiological, physical, and chemical stability for 28 days at refrigerated temperatures followed by 2 days at room temperature, supporting their centralized preparation and extended shelf-life in hospital pharmacy practice.
This study demonstrates that Pinus sp. leaf extracts exhibit potent, non-toxic antileishmanial activity against Leishmania donovani through antioxidant and immunomodulatory effects, with metabolomic and in silico analyses suggesting that flavanone O-glycosides, alkaloids, and diterpenes within the extracts inhibit the parasite via trypanothione reductase.
This study demonstrates that female Heterogeneous Stock rats consistently self-administer heroin and other opioids at higher rates than males, despite males exhibiting moderately greater sensitivity to heroin's anti-nociceptive effects.
This study reveals that while six common pharmaceuticals do not affect the germination of bok choy and spinach, they significantly alter early seedling development in a species-specific manner, with bok choy showing distinct growth disruptions in root systems and hormonal regulation compared to the more resilient spinach.
This paper proposes a mathematically rigorous "Ehrlich occupancy time" framework that extends beyond traditional residence time by integrating association kinetics, rebinding, and drug elimination to provide a comprehensive metric for predicting in vivo therapeutic efficacy.
This study demonstrates that modulating ion channels and cytoskeletal components induces concentration-dependent paralysis, structural damage, and mortality in *Echinococcus granulosus* protoscoleces, highlighting calcium fluxes and cytoskeletal organization as promising pharmacological targets for treating echinococcosis.
This study demonstrates that PROTACs rely on clathrin-mediated endocytosis, facilitated by CD36 adaptor motifs, to enter cells and induce target protein degradation, overturning the assumption of passive diffusion and highlighting a critical pathway for optimizing degrader therapeutics.
This study demonstrates that specific synergistic combinations of phytocannabinoids (CBD, CBG) and the sesquiterpene β-caryophyllene induce a novel, sequential cell death program in Triple-Negative Breast Cancer cells, characterized by an initial Na,K-ATPase-regulated autosis phase followed by apoptosis, thereby overcoming resistance to conventional apoptosis-based therapies.
This study demonstrates that trophoblast-derived extracellular vesicles can restore P-glycoprotein function in inflamed brain endothelial cells through a process called exofection, thereby enhancing amyloid-beta clearance and reducing neuroinflammation in Alzheimer's disease models.
Using mass spectrometry imaging in rhesus macaques, this study reveals that while antiretroviral therapy robustly increases phospholipid abundance across brain regions, its impact varies by location and often outweighs the effects of SIV infection, highlighting the need to further evaluate the neurologic consequences of disrupted lipid homeostasis under different treatment regimens.
This study demonstrates that low concentrations of cadmium exposure alter Jamaican fruit bat adaptive immune responses by upregulating B and T cell transcripts and inducing a Th2-dominant profile, without significantly affecting viral replication in kidney cells.
This study demonstrates that the ingestion of expanded polystyrene by wharf roaches (Ligia spp.) significantly disrupts their gut microbiome and alters gene expression, leading to increased abundance of specific archaea, eukaryotes, and viruses, which suggests a causal link between plastic pollution and enhanced viral activation and methane production in these coastal organisms.
This study demonstrates that chronic nicotine self-administration increases impulsive action in rats, a deficit specifically reduced by the nAChR antagonist mecamylamine but not by agonists or partial agonists, highlighting the utility of the Go/No-Go task for investigating nicotine-induced impulsivity.
This study identifies hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) as the direct molecular target of magnesium isoglycyrrhizinate (MgIG) and elucidates its therapeutic mechanism in alcohol-associated liver disease through the suppression of the HSD11B1-SREBP2-IDI1 signaling axis, which alleviates hepatic steatosis, inflammation, and apoptosis.
This study introduces steroid-based Tide Quencher 1 (TQ1) probes that enable real-time, residue-level mapping of novel non-canonical cholesterol-binding sites on the M1 muscarinic receptor, overcoming traditional assay limitations to facilitate structure-guided drug discovery targeting allosteric lipid-GPCR interactions.
This study characterizes the in vivo pharmacokinetics and tissue distribution of the anticancer cassane diterpene 6{beta}CHV in rats, demonstrating its feasible oral absorption, wide tissue penetration including sanctuary sites, and extensive retention, which supports its further preclinical development despite delayed systemic exposure.
This study demonstrates that the NAADP-binding protein JPT2/HN1L is essential for NAADP-mediated calcium signaling and T cell activation but is dispensable in cardiomyocytes, platelets, and mast cells, highlighting a striking cell-type specificity in its physiological function.
This study characterizes three distinct chitosan formulations and evaluates their effects on weaned piglets, finding that while advanced chemical analysis is crucial for precision nutrition, the tested dosages did not significantly improve growth, faecal consistency, or microbiota composition, suggesting that a higher threshold dose may be required to effectively manage post-weaning diarrhoea.
This study demonstrates that diminished apelin levels are associated with autosomal dominant polycystic kidney disease (ADPKD) and that exogenous apelin receptor activation inhibits cyst growth and improves kidney function in ADPKD mice, suggesting the apelin receptor as a promising therapeutic target.
This study demonstrates that the stapled peptide sulanemadlin specifically activates p53 in zebrafish by overcoming species-specific binding barriers that limit small-molecule inhibitors, thereby enabling the first pharmacological assessment of p53 regulation in vivo without inducing apoptosis.